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Voltarol spray uk -pfp, lisdexamfetamine, duloxetine) (3). Other studies investigated the antidepressant, anxiolytic or nootropic effects of sertraline compared with other SSRIs and antidepressant drugs (4). The current review focuses on its acute and prolonged effects. However, it should be emphasized that in the context of literature, sertraline is not considered a new class of drug when compared with other antidepressant drugs. The mechanism of action sertraline is not fully understood in humans, voltarol patch uk but it is presumed to involve stimulation of 5-HT 1A receptors and its activation by 5-HT in dopaminergic and serotonergic areas. This hypothesis is supported by the preclinical studies indicating 5-HT 1A receptor involvement in the cognitive and motor effects of sertraline, suggesting 5-HT may play a primary role. In contrast to this hypothesis, other researchers have proposed that antidepressant effects of sertraline are exerted at 5-HT 1A receptors (5). Indeed, in a rat model of stress stress-induced increases in extracellular 5-HT levels induced by administration of sertraline, a 5-HT 1A receptor agonist, are completely reversed by blockade of 5-HT 1A receptors (6; p = 0.025). In comparison with its long-term effects, acute sertraline administration may induce anxiolytic-like behavior. This hypothesis stems from the finding that acute buy voltarol tablets uk sertraline administration produces increased immobility time in the elevated plus-maze after a 7-day administration (7). Additionally, sertraline produced increased locomotor activity in rats given an anxiety-like behavioral protocol and enhanced open field behavior after a 7-day sertraline administration (8). However, most of the findings do not provide strong support of acute stress-induced anxiolytic-like effects sertraline. Interestingly, the prolonged of sertraline are not always interpreted as anxiolytic-like, but can be attributed to the fact that many of these studies included placebo controls and/or only a single day of administration to control for acute effects (4). In contrast to this finding, acute administrations of other antidepressants such as clomipramine and imipramine have been found to induce anxiolytic-like anxiolytic effects in rats (9-11). Similar to the short-term effects, acute administration of sertraline is also thought to have a significant influence on neuroadaptation and long-term behavioral performance, as suggested by the long-term consequences of chronic sertraline administration (12). Most of the data from animal model studies investigating the acute effects of sertraline use the classical test of forced swim voltarol emulgel uk (13) and open field test (2). A number of animal studies using the Porsolt swim test (14) and a maze of locomotor activity (15, 16) have reported anxiolytic-like effects of acute administration sertraline in rats. For example, administration of sertraline at the doses tested in these studies for anxiolytic-like effects reduced the amount of time spent under the Porsolt and open field test poles, improved working and memory performance (14; p < 0.05); however, the latter study used 2 mg/kg sertraline in the open field test. addition, in a study using novel swim test involving a 20-cm open-field chamber, the authors found significant anxiolytic effects of sertraline at doses for 4 days up to 18 mg/kg (17). In the present study using a novel maze test of exploratory behavior, the authors found significant anxiolytic-like side effects of sertraline at doses for 1-week that were at least five times higher than previous doses used to show anxiolytic-like effects in rodent models. As mentioned earlier, 2 mg/kg sertraline had no effect on swimming speed or time of rats given the classic Porsolt test, while it decreased the time spent under Porsolt pole by 42% in 4-day and 57% 8-day sertraline-treated rats (10). However, when given an anxiolitic-like protocol, chronic sertraline administration did not alter either swim speed or swimming time (10). These studies suggest that the dose of sertraline used in the present study may be insufficient to generate an anxiogenic response. Although it is unclear how to interpret the anxiolytic-like side effects induced by acute and chronic sertraline administration, most studies suggest that these effects are independent of 5-HT 1A receptors (3). Recently, Sadeghabadi et al. (2) also reported anxiolytic-like effects at sert.

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